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CoQ10 and Amyotrophic Lateral Sclerosis (ALS)

Lou Gehrig's Disease

 

Symptoms, Signs and Diagnosis

Amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. Motor neurons reach from the brain to the spinal cord and from the spinal cord to the muscles throughout the body. The progressive degeneration of the motor neurons in ALS eventually lead to their death. When the motor neurons die, the ability of the brain to initiate and control muscle movement is lost. With voluntary muscle action progressively affected, patients in the later stages of the disease may become totally paralyzed. Yet, through it all, for the vast majority of people, their minds remain unaffected.

 

Treatment

 

Link with CoQ10

CoQ10, a cofactor in mitochondrial electron transfer, may improve the mitochondrial dysfunction in Amyotrophic Lateral Sclerosis (ALS).

 

Medical Research

 

Title

Author 

Journal 

A two-stage design for a phase II clinical trial of coenzyme Q10 in ALS

Levy G, Kaufmann P, et al

Neurology 2006;66:660-663

Coenzyme Q10 as a possible treatment for neurodegenerative disease.

Beal MF. 

Free Radic. Res. 2002; 36(4): 455-60

Serum levels of coenzyme Q10 in patients with amyotrophic lateral sclerosis.

Molina JA, et al.

J. Neural Transm. 2000; 107 (8-9):1021-6

Coenzyme Q10 administration increases brain mitochondrial
concentrations and exerts neuroprotective effects.
 (Full Article Download)

Matthews RT, et al. 

Proc. Natl. Acad. Sci. U. S. A. 1998; 95(15):8892-7 

Tolerance of high-dose (3,000) mg/day) coenzyme Q10 in ALS

K.L.Ferrante, et al. 

Neurology 2005;65:11:1834-36. 

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More Information
 
For more information on how to enroll your medical center or private practice in our Physician Referral Program, contact us at:
 
Vitaelin Healthcenter
Physician Referral Program
4960 South Gilbert Road,
Suite 1-286
Chandler, AZ 85249
 
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